Relation of insulin like growth factor and glycocylated hemoglobin at different gestational periods of pregnancy in diabetic pregnant women

Bushra Abdulameer, Ali Shabaa


Background: Diabetes mellitus complicating pregnancy is one of the most common antenatal complications that are associated with significant perinatal mortality and morbidity. Insulin like growth factor-1 (IGF-1) has been implicated with micro-vascular complications during pregnancy. Glycosylated hemoglobin (HbA1c) is a reliable index, used to evaluate the glycemic control at the last 8 weeks. Aim: To find the relation between the level of insulin like growth factor and HbA1c at different gestational periods of pregnancy in diabetic pregnant women. Methods: The study was carried out on 190 pregnant women. They were 134 pregnant women with abnormal carbohydrate metabolism and 56 healthy pregnant women. Those of abnormal carbohydrate metabolism were also classified into two groups, those with gestational diabetes mellitus (70) and those with pregestational diabetes mellitus (64). IGF-1 and HbA1c levels were measured in the studied pregnant women at the second and third trimesters of pregnancy. Results: IGF-1 concentrations was found to be higher in patients with GDM when compared with those of PGDM and the control groups, in both 2nd and 3rd trimesters with a significant (P <0.001) difference among subgroups. HbA1c concentrations were found to be significantly (P< 0.001) higher in pregnant women with GDM and PGDM than in the control group. There was a significant (r=0.27, P<0.001) weak correlation between IGF-1 and HbA1c in both 2nd and 3rd trimesters. Conclusion: Both, IGF-1 and HbA1c levels elevate in pregnant women with GDM and PGDM, such rise is manifested by a weak positive correlation between the concentrations of the two parameters. Recommendation: It is useful to study the role of IGF-1 therapy in pregnant with diabetes mellitus especially those with vasculopathy.

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