A comparative study for GLP-1 levels in Iraqi diabetic patients with hyper & hypothyroidism

Zeinab Moneb. Al-Rubaei, Usama Salman. Al timari, Huda Ahmed. Alobaydi

Abstract


The current study aimed to determine   GLP-1 levels in hyper and hypothyroidism disease with diabetic and compared the results with a control group. The study also aimed to find the relationship for GLP-1 with (TSH, T3and insulin) in   patients groups. The study involved 30 subjects with hyperthyroidism and diabetic as group 1(G1), and 30 subjects hypothyroidism patients with diabetes as group 2 (G2) to 30 healthy controls as group 3 (G3). The subjects were matched aged of (40-65 years). Serum used in determination T3, TSH, FBG and insulin in the control and patients groups, the BMI and IR were also calculated. Results showed highly significant increase in T3 levels in G1 contrast to G3 while there are no significant decreasing was found in G2 contrast to G3.Results in this study revealed highly significant decreasing in TSH levels in G1 contrast to G3 with highly significant increase in G2 comparing to G3.  Results illustrate levels of FBG   in all studied groups, which showed highly significant increase in FBG in G1 and G2 comparing to G3. Results showed highly significant increase in insulin   levels in G1 contrast to G3 while there are no significant different observed in G1 contrast to G2. Results, also, showed highly significant increasing in GLP-1 in G1 and G2 when compared to G3.Correlation relation of GLP-1with T3, TSH and insulin were studied. Result revealed significant positive correlation between GLP-1 and T3 in G3 (P≤0.5, r = 0.350) while a significant negative correlation was observed in G1 and G2 (P≤0.05, r = -.047, r = -0.55). Results revealed significant positive correlation in G3 between TSH and T3 (P≤0.05, r = -.055) while a significant negative correlation (P≤0.05, r = -.047, r =.386) was observed in G1 and G2.  Study also showed the correlation relation between GLP-1 and insulin there are no significant positive relation was seen in G3 (P˃0.05, r = 0.083), while showed highly significant positive correlation   in G1 and G2 (r = 0.55, r = 0.344). It is Concluded from this study that GLP-1 can be used as a marker in diagnostic and monitoring   the development in diabetes to its complication in these patients.


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