Breast cancer chemotherapy using nano-drug delivery system in a mouse model

Imad AlSabri, Sabah Mraisen, Batool Hatem, Zuhair Allebban

Abstract


Purpose: Gold nanoparticles (AuNPs) can be used as delivery vehicles for platinum anticancer drugs, improving their targeting and uptake into cells. Cisplatin, cis-diamminedichloridoplatinum (II), is the leading metallodrug used in the systemic treatment of solid tumors.

The aim of the current study, to evaluate both in vitro and in vivo anti-tumor efficacy of gold nanoparticles (GNPs) conjugated with conventional chemotherapy drug, cisplatin for the treatment of breast cancer, using preclinical animal model.

Methods: GNPs, were successfully used as a complex tumor-targeting drug-delivery system. The drug cisplatin, was non-covalently conjugated onto the hydrophilic assemblies of GNPs-nanostructure.

Results: The cancer cells toxicity and viability in the presence of the anti-cancer drugs delivered by the GNPs were found to be statistically more effective than those of cells exposed to the traditional cancer drug alone.  Post treatment with cisplatin and cisplatin-nanogold conjugate indicated that cispaltin-treated group has their relative treated volume (RTV) continuously increased while animals treated with cisplatin-nanogold continuously decreased. Histologically, the tumor cell density of cisplatin-nanogold conjugate -treated animals are less than those treated with cisplatin alone.

Conclusion: This pilot study could offer a new chemotherapy strategy for patients diagnosed with breast cancer. The late effect of cisplatin-nanogold on RTV at day 24 could be a significant chemodynamic of the drug on tumor eradication.


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