Study of anti- inflammatory effect of Tribulus terrestris extract on bacterial infected wounds in mice

Rebah Najah Jabbar AL-gafari, Rehab Subhi Ramadhan

Abstract


The effect of water extract from Tribulus terrestris was studied as an anti-inflammatory agent on albino mice with Staph aureus infected wounds and investigating the toxicity of this substance. Two groups with ten mice in each one were used to conclude this part. The first one served as control that was wounded and infected by Staphylococcus aureus  and left for normal healing , while the other group was treated with the extract after wounds were contaminated and infected with Staphylococcus aureus. The results showed an accelerated healing in wounds treated with T. terrestris compared with control. The cytotoxicity was performed on three groups of mice; every group included ten mice divided as: control group, the second group was orally administrated with 75mg/kg of the aqueous extract; the third group was administrated orally with 25mg/kg of the aqueous extract. The administration last for 10 days. After 10 days, mice were killed and put for autopsy histology slides were made from kidney and liver and compared with control group. No change was observed among studied slides which may indicate that the extract has no toxic effect on organs.

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