The correlation between oral warfarin intake and two pro-inflammatory cytokines (IL-6 and TNF-α ) and their effects on atherosclerosis in deep venous thrombosis disease.

Dina A. A. AL-Roubaey


Warfarin is a commonly used medication for the prevention and treatment of deep venous thrombosis disease. The purpose of this study was to identify the association between warfarin dose and pro-inflammatory cytokines production during the treatment and the effect of this interaction on the development and progression of atherosclerosis in patients with deep venous thrombosis disease. The study was carried out in Al-Sadr Medical City in Al- Najaf province, during the period from Apr, to Dec, 2016. The study involved  (70) patients with deep venous thrombosis disease who attended the hospital. The majority of the studies were men  (71.4 %) and the most effected age group was from 65 to 74 years old in percentage (44%)  followed by the age group 55 to 64 years old in percentage (32%), also the present study showed a highly significant increased mean serum level of IL-6  (464.1 vs. 183.1 pg /ml) and TNF-α  (479.2 vs. 191.3 pg/ml) in patients as compared to the  corresponding  controls , in addition, the results showed that the highly significant increase in both cytokines were in warfarin dose 10 mg/day followed by dose 7.5 and 5 mg/day . It was concluded that warfarin in high doses may have a critical role in the initiation and development of atherosclerosis through its effect on pro-inflammatory cytokines production. It was recommended to achieve a comprehensive investigation for evaluating the side effect of warfarin in high doses on inflammatory process that cause another damage of the immune system leading to atherosclerosis. 

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