Relationship between Rheumatoid arthritis and anemia of chronic disease of patient in province Diwaniya

Hussein Mahdi kreem AL-Mohammad

Abstract


Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis in adults. Rheumatoid arthritis is also a chronic destructive inflammatory disease characterized by the accumulation and of an inflammatory infiltrate in the synovial membrane that leads to sinusitis and the destruction of the joint architecture resulting in impaired function. The anemia of chronic disease (ACD) is a result of Body response to inflammation or system disease. ACD, usually a mild to moderate anemia, is the most prevalent anemia after iron deficiency anemia and also the most prevalent anemia in hospitalized patients. This anemia, first described in chronic infections, may be found in subjects with diseases involving acute or chronic immune activation and thus could be seen in a variety of inflammatory conditions, acute or chronic Infections, rheumatologic disorders, autoimmune disorders and cancer. The study includes thirteen (20 female and 10 male)  patient  with RA and (10 male and 20 female ) as the control. In the present study, significantly increased (p < 0.05)  At ferretin , and significant decrease (p < 0.05).   In Hb, iron, transferitin, transferin saturated.

 These results suggest Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, primarily located in the synovial joints, Anemia of chronic disease is anemia connected with inflammation or system disease. It is mediated by inflammatory cytokines TNF, IL-1, IL-6 and IFN that engulf iron than iron metabolism dysregulation, decreased RBC production in bone marrow, shortening the RBC lifespan, and decreased erythropoietin secretion. 


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