Study of some physiological parameters in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Rafie S. Al-Khafaji, Haider K. Zaidan, Ali H. Al-Saadi

Abstract


Autosomal dominant polycystic kidney disease (ADPKD) is the most common Mendelian disorder of the kidney and affects all racial groups worldwide. It is characterized by focal development of renal and extrarenal cysts in an age-dependent manner. This study tested some physiological parameters in two groups of patients with ADPKD, the first group included patients with kidney failure and the second group included patients without renal failure as well as the control group. The study showed an increase in urea and uric acid in the serum of the patients without renal failure compared with the control levels and were higher in the patients with renal failure compared with the patients without renal failure, which amounted to 115.8 mg / dL and 10,278 mg / dL and 22.45 mg / dL and 7,264 mg / dL and 11.03 mg / dL and 3,264 mg /dL respectively. Creatinine serum level was higher in the patients with renal failure compared with the patients without renal failure and control, reaching 3.5 mg / dL , compared with 1,026 mg / dL and 0986 mg / dL , respectively. Potassium ion level was higher in patients without renal failure than in control reaching 4,179 mmol / L and 2.34 mmol / L, respectively, while the level was higher in patients with renal failure than in patients without renal failure where it reached 7.09 mmol / l. Sodium ion levels were low in the patients with renal failure and the patients without renal failure than in the control group, reaching 87.06 mmol / l and 129 843 mmol / l and 147.25 mmol / L, respectively. The level of sodium ion was lower in the patients with renal failure than in the patients without renal failure. Results of the study showed normal levels in serum albumin and liver enzymes, AST and ALT.


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